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2025年
An Extensive Survey of Vertebrate-specific, Nonvisual Opsins Identifies a Novel Subfamily, Q113-Bistable Opsin.
Genome Biol Evol. 2025;17(3):evaf032. doi:10.1093/gbe/evaf032.
Abstract
Fukuda A, Sato K, Fujimori C, Yamashita T, Takeuchi A, Ohuchi H, Umatani C, Kanda S.
Direct photoreception by pituitary endocrine cells regulates hormone release and pigmentation.
Science. 2025;387(6729):43-48. doi:10.1126/science.adj9687.
Abstract
Kobayashi Y, Edamura K, Sadahira T, Tominaga Y, Katayama S, Iwata T, Nishimura S, Kobayashi T, Sato K, Komiyama T, Momota R, Ohuchi H, Araki M.
What is the identity of Gerota fascia? Histological study with cadavers.
Int J Urol. 2025;32(1):62-68. doi: 10.1111/iju.15596.
Abstract
2024年
Functional diversification process of opsin genes for teleost visual and pineal photoreceptions.
Cell Mol Life Sci. 2024;81(1):428. doi: 10.1007/s00018-024-05461-3.
Abstract
Ono-Minagi H, Nohno T, Takabatake K, Tanaka T, Katsuyama T, Miyawaki K, Wada J, Ibaragi S, Iida S, Yoshino T, Nagatsuka H, Sakai T, Ohuchi H.
Histological differences related to autophagy in the minor salivary gland between primary and secondary types of Sjögren's syndrome.
BMC Oral Health. 2024;24(1):1099. doi: 10.1186/s12903-024-04869-4.
Abstract
Ikeda S, Sato K, Fujita H, Ono-Minagi H, Miyaishi S, Nohno T, Ohuchi H.
Harderian Gland Development and Degeneration in the Fgf10-Deficient Heterozygous Mouse.
J Dev Biol. 2024;12(2):16. doi: 10.3390/jdb12020016.
Abstract
Sato K, Ohuchi H.
Molecular Property, Manipulation, and Potential Use of Opn5 and Its Homologs.
J Mol Biol. 2024;436(5):168319. doi: 10.1016/j.jmb.2023.168319.
Abstract
2023年
The Germinal Origin of Salivary and Lacrimal Glands and the Contributions of Neural Crest Cell-Derived Epithelium to Tissue Regeneration.
Int J Mol Sci. 2023;24(18):13692. doi: 10.3390/ijms241813692.
Abstract
Sato K, Yamashita T, Ohuchi H.
Mammalian type Opsin 5 preferentially activates G14 in Gq-type G proteins triggering intracellular calcium response.
J Biol Chem. 2023:105020. doi: 10.1016/j.jbc.2023.105020.
Abstract
Fujiyabu C, Sato K, Ohuchi H, Yamashita T.
Diversification processes of teleost intron-less opsin genes.
J Biol Chem. 2023;299(7):104899. doi: 10.1016/j.jbc.2023.104899.
Abstract
Ono-Minagi H, Gojo N, Nohno T, Inoue T, Ohuchi H, Sakai T.
Evaluation of oral care using MA-T gel for high-risk patients: a pilot study.
BMC Oral Health. 2023;23(1):108. doi: 10.1186/s12903-023-02779-5.
Abstract
Sato K, Liu Y, Yamashita T, Ohuchi H.
The medaka mutant deficient in eyes shut homolog exhibits opsin transport defects and enhanced autophagy in retinal photoreceptors.
Cell Tissue Res. 2023;391(2):249-267. doi: 10.1007/s00441-022-03702-0.
Abstract
Mizuno M, Sato K, Yamashita T, Sakai K, Imamoto Y, Yamano Y, Wada A, Ohuchi H, Shichida Y, Mizutani Y.
Chromophore Structure in an Inactive State of a Novel Photosensor Protein Opn5L1: Resonance Raman Evidence for the Formation of a Deprotonated Adduct at the 11th Carbon Atom.
J Phys Chem B. 2023. doi: 10.1021/acs.jpcb.2c08780.
Abstract
2022年
Involvement of a Basic Helix-Loop-Helix Gene BHLHE40 in Specification of Chicken Retinal Pigment Epithelium.
J Dev Biol. 2022;10(4):45. doi: 10.3390/jdb10040045.
Abstract
Kanzaki Y, Fujita H, Sato K, Hosokawa M, Matsumae H, Morizane Y, Ohuchi H.
Protrusion of KCNJ13 Gene Knockout Retinal Pigment Epithelium Due to Oxidative Stress-Induced Cell Death.
Invest Ophthalmol Vis Sci. 2022;63(12):29. doi: 10.1167/iovs.63.12.29.
Abstract
Bando T, Okumura M, Bando Y, Hagiwara M, Hamada Y, Ishimaru Y, Mito T, Kawaguchi E, Inoue T, Agata K, Noji S, Ohuchi H.
Toll signalling promotes blastema cell proliferation during cricket leg regeneration via insect macrophages.
Development. 2022;149(8):dev199916. doi: 10.1242/dev.199916.
Abstract
Fujiyabu C, Sato K, Nishio Y, Imamoto Y, Ohuchi H, Shichida Y, Yamashita T.
Amino acid residue at position 188 determines the UV-sensitive bistable property of vertebrate non-visual opsin Opn5.
Commun Biol. 2022;5(1):63. doi: 10.1038/s42003-022-03010-x.
Abstract
Fujita H, Ando A, Mizusawa Y, Ono M, Hattori T, Habuta M, Oohashi T, Kubota S, Ohuchi H.
Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption.
PLoS One. 2022;17(11):e0277307. doi: 10.1371/journal.pone.0277307.
Abstract
Xue R, Lin W, Fujita H, Sun J, Kinoshita R, Ochiai K, Futami J, Watanabe M, Ohuchi H, Sakaguchi M, Tang Z, Huang P, Nasu Y, Kumon H.
Dkk3/REIC Deficiency Impairs Spermiation, Sperm Fibrous Sheath Integrity and the Sperm Motility of Mice.
Genes (Basel). 2022;13(2):285. doi: 10.3390/genes13020285.
Abstract
2021年
UCP1 expression in the mouse adrenal gland is not upregulated by thermogenic conditions.
Biochem Biophys Res Commun. 2021;566:184-189. doi: 10.1016/j.bbrc.2021.06.013.
Abstract
The Opsin 3/Teleost multiple tissue opsin system: mRNA localization in the retina and brain of medaka (Oryzias latipes).
J Comp Neurol. 2021 Jan 11. doi: 10.1002/cne.25106.
Abstract
2020年
Functional analysis of Pdp1 and vrille in the circadian system of a cricket.
J Insect Physiol. Nov-Dec 2020;127:104156.doi: 10.1016/j.jinsphys.2020.104156.
Abstract
The role of clockwork orange in the circadian clock of the cricket Gryllus bimaculatus.
Zoological Lett. 2020 Nov 11;6(1):12.doi: 10.1186/s40851-020-00166-4.
Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung.
PLoS One. 2020 Oct 15;15(10):e0240333. doi: 10.1371/journal.pone.0240333.
Abstract
Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland.
Acta Med Okayama. 2020 Jun;74(3):199-208. doi: 10.18926/AMO/59950.
Abstract
KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells..
Invest Ophthalmol Vis Sci. 2020 May 11;61(5):38. doi: 10.1167/iovs.61.5.38.
Abstract
Dickkopf3 (Dkk3) is required for maintaining the integrity of secretory vesicles in the mouse adrenal medulla.
Cell Tissue Res. 2020 Jan;379(1):157-167. doi: 10.1007/s00441-019-03113-8.
Abstract
2019年
Localization of the ultraviolet-sensor Opn5m and its e ect on myopia-related gene expression in the late-embryonic chick eye.
Biochem Biophys Rep. 2019 19:100665. doi: 10.1016/j.bbrep.2019.100665.
Abstract
Fujiyabu C, Sato K, Utari NML, Ohuchi H, Shichida Y, Yamashita T.
Evolutionary history of teleost intron-containing and intron-less rhodopsin genes.
Sci Rep. 2019 9:10653. doi: 10.1038/s41598-019-47028-4.
Abstract
Ohuchi H, Sato K, Habuta M, Fujita H, Bando T.
Congenital eye anomalies: More mosaic than thought?
Congenit Anom (Kyoto). 2019 59:56-73.
Abstract
Glutathione accelerates osteoclast differentiation and inflammatory bone destruction.
Free Radic Res. 2019 Mar 1:1-11. doi: 10.1080/10715762.2018.1563782.
Abstract
2018年
Metabolic abnormalities in adult T-cell leukemia/lymphoma and induction of specific leukemic cell death using photodynamic therapy.
Sci Rep. 2018 Oct 8;8(1):14979. doi: 10.1038/s41598-018-33175-7.
Abstract
Zoological Lett (2018) 4, 26.
Abstract
Sato K, Yamashita T, Kojima K, Sakai K, Matsutani Y, Yanagawa M, Yamano Y, Wada A, Iwabe N, Ohuchi H, Shichida Y.
Pinopsin evolved as the ancestral dim-light visual opsin in vertebrates
Communications Biology volume 1, Article number: 156 (2018)
Abstract
Ishimaru Y, Bando T, Ohuchi H, Noji S, Mito T.
Bone morphogenetic protein signaling in distal patterning and intercalation during leg regeneration of the cricket, Gryllus bimaculatus.
Dev Growth Differ. 2018 Aug;60(6):377-386. doi: 10.1111/dgd.12560.
Abstract
Bando T, Mito T, Hamada Y, Ishimaru Y, Noji S, Ohuchi H.
Molecular mechanisms of limb regeneration: insights from regenerating legs of the cricket Gryllus bimaculatus.
Int J Dev Biol. 2018;62(6-7-8):559-569. doi: 10.1387/ijdb.180048ho.
Abstract
Sato K, Yamashita T, Ohuchi H, Takeuchi A, Gotoh H, Ono K, Mizuno M, Mizutani Y, Tomonari S, Sakai K, Imamoto Y, Wada A, Shichida Y.
Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor.
Nat Commun. 2018 Mar 28;9(1):1255. doi: 10.1038/s41467-018-03603-3.
Abstract
2017年
Zoological Lett (2017) 3, 5.
Abstract
Yasue A, Kono H, Habuta M, Bando T, Sato K, Inoue J, Oyadomari S, Noji S, Tanaka E, Ohuchi H.
Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities-an analysis of CRISPR genome-edited mouse embryos.
Sci Rep (2017) 7, 53.
Abstract
Inoue J, Fujita H, Bando T, Kondo Y, Kumon H, Ohuchi H.
Expression analysis of Dickkopf-related protein 3 (Dkk3) suggests its pleiotropic roles for a secretory glycoprotein in adult mouse.
J Mol Histol (2017) 48, 29-39.
Abstract
Ohuchi H, Bando T, Mito T, Noji S.
Eye development and photoreception of a hemimetabolous insect, Gryllus bimaculatus.
The Cricket as a Model Organism Development, Regeneration, and Behavior. Horch HW, Mito T, Popadic A, Ohuchi H, Noji S., Springer, (2017), 49-62.
Bando T, Hamada Y, Noji S.
Leg formation and regeneration.
The Cricket as a Model Organism Development, Regeneration, and Behavior. Horch HW, Mito T, Popadic A, Ohuchi H, Noji S., Springer, (2017), 31-48.
2016年
Two Opsin 3-Related Proteins in the Chicken Retina and Brain: A TMT-Type Opsin 3 Is a Blue-Light Sensor in Retinal Horizontal Cells, Hypothalamus, and Cerebellum.
PLoS One. 2016 Nov 18;11(11):e0163925.
Abstract
Kutaragi Y, Miki T, Bando T, Tomioka K.
Transcriptional and nontranscriptional events are involved in photic entrainment of the circadian clock in the cricket Gryllus bimaculatus
Physiological Entomology. 2016 December; 41(4):358?68.
Abstract
Sato K, Yamashita T, Haruki Y, Ohuchi H, Kinoshita M, Shichida Y.
Two UV-Sensitive Photoreceptor Proteins, Opn5m and Opn5m2 in Ray-Finned Fish with Distinct Molecular Properties and Broad Distribution in the Retina and Brain.
PLoS One. 2016 May 11;11(5):e0155339.
Abstract
Ishimaru Y, Tomonari S, Matsuoka Y, Watanabe T, Miyawaki K, Bando T, Tomioka K, Ohuchi H, Noji S, Mito T.
TGF-β signaling in insects regulates metamorphosis via juvenile hormone biosynthesis.
Proc Natl Acad Sci U S A. 2016 May 17;113(20):5634-9.
Abstract
Fujita H, Nagakawa K, Kobuchi H, Ogino T, Kondo Y, Inoue K, Shuin T, Utsumi T, Utsumi K, Sasaki J, Ohuchi H.
Phytoestrogen Suppresses Efflux of the Diagnostic Marker Protoporphyrin IX in Lung Carcinoma.
Cancer Res. 2016 Apr 1;76(7):1837-46.
Abstract
Ohuchi H, Taniguchi K, Miyaishi S, Kono H, Fujita H, Bando T, Fuchizawa C, Ohtani Y, Ohtani O.
Autopsy Case of Bilateral Optic Nerve Aplasia with Microphthalmia: Neural Retina Formation Is Required for the Coordinated Development of Ocular Tissues.
Acta Med Okayama. 2016 Apr;70(2):131-137.
Abstract
Hamada Y, Tokuoka A, Bando T, Ohuchi H, Tomioka K.
Enhancer of zeste plays an important role in photoperiodic modulation of locomotor rhythm in the cricket, Gryllus bimaculatus.
Zoological Lett. 2016 Mar 19;2:5.
Abstract
板東哲哉、濱田良真、奥村美紗、坂東優希、大内淑代
昆虫に学ぶ器官再生
ケミカルタイムズ 2016 Jul; 241:2-6.
Full text
2015年
Leg regeneration is epigenetically regulated by histone H3K27 methylation in the cricket Gryllus bimaculatus.
Development. 2015 Sep 1;142(17):2916-27.
Abstract
Matsuoka Y, Bando T, Watanabe T, Ishimaru Y, Noji S, Popadi? A, Mito T.
Short germ insects utilize both the ancestral and derived mode of Polycomb group-mediated epigenetic silencing of Hox genes.
Biol Open. 2015 May 6. pii: bio.011064. doi: 10.1242/bio.201411064.
Abstract
Ishimaru Y, Nakamura T, Bando T, Matsuoka Y, Ohuchi H, Noji S, Mito T.
Involvement of dachshund and Distal-less in distal pattern formation of the cricket leg during regeneration.
Sci Rep. 2015 Feb 11;5:8387. doi: 10.1038/srep08387.
Abstract
2014年
An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system.
Sci Rep. 2014 Mar 11;4:4335. doi: 10.1038/srep04335.
Abstract
Yamashita T, Ono K, Ohuchi H, Yumoto A, Gotoh H, Tomonari S, Sakai K, Fujita H, Imamoto Y, Noji S, Nakamura K, Shichida Y.
Evolution of Mammalian Opn5 as a Specialized UV-absorbing Pigment by a Single Amino Acid Mutation.
J Biol Chem. 2014 Feb 14;289(7):3991-4000. doi: 10.1074/jbc.M113.
Abstract
板東哲哉、三戸太郎、野地澄晴、大内淑代
コオロギ脚再生の分子メカニズム
実験医学 2014 Jan; 32 (1):15-21.
2013年
The expression of LIM-homeobox genes, Lhx1 and Lhx5, in the forebrain is essential for neural retina differentiation.
Dev Growth Differ. 2013 Sep;55(7):668-75. doi: 10.1111/dgd.12074.
Abstract
Ohuchi H.
Molecular aspects of eye evolution and development: from the origin of retinal cells to the future of regenerative medicine.
Acta Med Okayama. 2013 Aug;67(4):203-12. Review.
Abstract
Takamori Y, Wakabayashi T, Mori T, Kosaka J, Yamada H.
Organization and cellular arrangement of two neurogenic regions in the adult ferret (mustela putorius furo) brain.
J Comp Neurol. 2013 Nov 9. doi: 10.1002/cne.23503.
Abstract
Komatsu S, Wakabayashi T, Yamada K, Matsumoto K, Kimata Y, Kosaka J.
Vascularized peripheral nerve grafting promotes myelination of regrowing optic nerve. Neuroreport. 2013 Jul 10;24(10):566-71. doi: 10.1097/WNR.0b013e3283625b39.
Abstract
Inoue K, Fukuhara H, Kurabayashi A, Furihata M, Tsuda M, Nagakawa K, Fujita H, Utsumi K, Shuin T.
Photodynamic therapy involves an antiangiogenic mechanism and is enhanced by ferrochelatase inhibitor in urothelial carcinoma.
Cancer Sci. 2013 Jun;104(6):765-772. doi: 10.1111/cas.12147.
Abstract
Yamamoto M, Fujita H, Katase N, Inoue K, Nagatsuka H, Utsumi K, Sasaki J, Ohuchi H.
Improvement of the Efficacy of 5-aminolevulinic Acid-mediated Photodynamic Treatment in Human Oral Squamous Cell Carcinoma HSC-4.
Acta Med Okayama. 2013 Jun;67(3):153-164.
Abstract
Fujita H, Yamamoto M, Ogino T, Kobuchi H, Ohmoto N, Aoyama E, Oka T, Nakanishi T, Inoue K, Sasaki J.
Necrotic and apoptotic cells serve as nuclei for calcification on osteoblastic differentiation of human mesenchymal stem cells in vitro.
Cell Biochem Funct. 2013 May 8. doi: 10.1002/cbf.2974.
Abstract
Weng L, Lin YF, Li AL, Wang CE, Yan S, Sun M, Gaertig MA, Mitha N, Kosaka J,Wakabayashi T, Xu X, Tang B, Li S, Li XJ.
Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.
J Neurosci. 2013 May8;33(19):8172-84. doi: 10.1523/JNEUROSCI.0119-13.2013.
Abstract
Analysis of RNA-Seq data reveals
involvement of the JAK/STAT signalling during leg regeneration of the cricket Gryllus bimaculatus.
Development. 2013 Mar; 140(5):959-64.
Abstract
大内淑代
組織形成因子Fgf10
岡山医学会雑誌 2013 125 (3):229-34.
ルイス ウォルパート (著) 大内淑代・野地澄晴 (訳)
発生生物学 (サイエンス・パレット) 生物はどのように形づくられるか
丸善出版
2012年
Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation.
PLoS One. 2012;7(11):e50082. doi: 10.1371/journal.pone.0050082.
Abstract
Wakabayashi T, Kosaka J, Mori T, Yamada H.
Prolonged expression of Puma in cholinergic amacrine cells during the development of rat retina.
J Histochem Cytochem. 2012 Oct;60(10):777-88.
Abstract
Kawaue T, Okamoto M, Matsuyo A, Inoue J, Ueda Y, Tomonari S, Noji S, Ohuchi H.
Lhx1 in the proximal region of the optic vesicle permits neural retina development in the chicken.
Biol Open. 2012 Nov 15;1(11):1083-93.
Abstract
Ohuchi H.
Wakayama symposium: epithelial-mesenchymal interactions in eyelid development.
Ocul Surf. 2012 Oct;10(4):212-6.
Abstract
Wang DH, Ootsuki Y, Fujita H, Miyazaki M, Yie Q, Tsutsui K, Sano K, Masuoka N, Ogino K.
Resveratrol inhibited hydroquinone-induced cytotoxicity in mouse primary hepatocytes.
Int J Environ Res Public Health. 2012 Sep 19;9(9):3354-3364.
Abstract
Watanabe T, Ochiai H, Sakuma T, Horch HW, Hamaguchi N, Nakamura T, Bando T, Ohuchi H, Yamamoto T, Noji S, Mito T.
Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases.
Nat Commun. 2012;3:1017.
Abstract
Takagi A, Kurita K, Terasawa T, Nakamura T, Bando T, Moriyama Y, Mito T, Noji S, Ohuchi H.
Functional analysis of the role of eyes absent and sine oculis in the developing eye of the cricket Gryllus bimaculatus.
Dev Growth Differ. 2012 Feb;54(2):227-40.
Abstract
Ohuchi H, Yamashita T, Tomonari S, Fujita-Yanagibayashi S, Sakai K, Noji S, Shichida Y.
A non-mammalian type opsin 5 functions dually in the photoreceptive and non-photoreceptive organs of birds.
PLoS One. 2012;7(2):e31534.
Abstract